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| Product Name: | Tetracaine HCL | CAS: | 136-47-0 |
|---|---|---|---|
| Appearance: | White Solid | Usage: | Local Anesthetic |
| Origin: | China | Purity: | 99% |
| High Light: | benzocaine hcl powder,procaine hcl powder |
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136-47-0 Local Anesthetic Tetracaine HCL Powder White Solid Odorless
| Product name | Tetracaine HCL powder |
| CAS No | 136-47-0 |
| Purity | 99% |
| Molecular | C15H24N2O2.Hcl |
| MW | 300.82 |
| Standard | BP 2000/USP 28 |
| EINECS | 205-248-5 |
| Appearance | White Solid |
Tetracaine HCL Specification :
| 1. | Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide |
| 2. | Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. |
| 3. | In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores |
| 4. | Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. |
| 5. | Tetracaine is the T in TAC, a mixture of 5 to 12 per cent tetracaine, 0.05 per cent adrenaline, and 4 or 10 per centcocaine hydrochloride used in ear, nose and throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations |
| 6. | A systematic review investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties. However, it did not find an improvement in first attempt cannulations |
COA:
| Test Items | Specification | Test Results |
| Appearance | Fine, white, crystalline, odorless powder | confirm |
| Identification | ABC in Pass | confirm |
| Solubility | Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene |
confirm |
| USP Reference standards | USP Tetracaine Hydrochloride RS. USP Endotoxin RS. |
confirm |
| Melting point | 145~150 degree | 146.0~147.5 degree |
| Chromatographic purity | In Pass | confirm |
| Related substance | Not more than the reference solution 0.05% | confirm |
| Heavy metals | ≤10ppm | confirm |
| PH | 4.5-6.5 | 5.8 |
| Residue on ignition | ≤0.10% | 0.04% |
| Loss on Drying | ≤ 0.5% | 0.16% |
| Assay | 98.0 -101.0% | 99.9% |
| Conclusion | Confirms USP 32 | |
