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Pentadecapeptide BPC 157 Anti Inflammatory Medication Anabolic Steroids CAS 137525-51-0

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Pentadecapeptide BPC 157 Anti Inflammatory Medication Anabolic Steroids CAS 137525-51-0

China Pentadecapeptide BPC 157 Anti Inflammatory Medication Anabolic Steroids CAS 137525-51-0 supplier
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Product Details:

Place of Origin: China
Brand Name: GB
Certification: ISO9001

Payment & Shipping Terms:

Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: as your require
Delivery Time: 3 work days
Payment Terms: Western Union, MoneyGram, , T/T
Supply Ability: 1000 kit per month
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Detailed Product Description
Product Name: Pentadecapeptide BPC 157 CAS: 137525-51-0
Appearance: White Freeze-dried Powder Specification: 2mg/vial
Alias: Booly Protection Compound 15, Pentadecapeptide, BPC 157 Origin: China
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Pentadecapeptide BPC 157 Anti Inflammatory Medication Anabolic Steroids CAS 137525-51-0​

 

 

Product name Pentadecapeptide BPC 157
Alias Booly Protection Compound 15, Pentadecapeptide, BPC 157
Sequence Gly-Glu-Pro-Pro-Pro-Gly- Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
CAS 137525-51-0
MF C62H98N16O22
MW 1419.53552
Purity 99%
Appearance White Lyophilized Powder
Specification 2mg/vial   10vials/kit
Origin China

 

 

 

 

 

 

 

 

 

 

 

 

Description:

1. BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease.

 

2. BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect. In addition, it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect.

 

3. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.

4. FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts. Likewise, Western blot analysis was able to detect the production and activation of paxillin and FAK proteins.

 

5. The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced

 

6. BPC 157 has a strong anti-inflammatory activity in both acute and chronic inflammation models. In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease.

 

7. BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect. In addition, it significantly facilitates the healing of bone fracture in rats. This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect.

 

8. BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.

9. Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon.

10. This study was designed to investigate the potential mechanism of BPC 157 to enhance healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined.

 

11. Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay.

12. However, the survival of BPC 157-treated cells was significantly increased under the H(2)O(2) stress. BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay.

 

13. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157-treated fibroblasts.

 

14. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered.

 

Storage :

 

Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.

 

Pentadecapeptide BPC 157 Anti Inflammatory Medication Anabolic Steroids CAS 137525-51-0
 

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