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SR9011 SARM Steroids / SARMS Raw Powder CAS 1379686-29-9

Good quality Testosterone Anabolic Steroid for sales
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SR9011 SARM Steroids / SARMS Raw Powder CAS 1379686-29-9

China SR9011 SARM Steroids / SARMS Raw Powder CAS 1379686-29-9 supplier

Large Image :  SR9011 SARM Steroids / SARMS Raw Powder CAS 1379686-29-9

Product Details:

Place of Origin: China
Brand Name: GB
Certification: ISO9001

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: pls quote
Packaging Details: foil bag
Delivery Time: 3 days
Payment Terms: Western Union, MoneyGram
Supply Ability: 100kg
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Detailed Product Description
Product Name: SR9011 Category: Sarm Steroids
CAS: 1379686-29-9 Appearance: White Powder
Usage: Muscle Strong Origin: China
High Light:

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1. SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.

 

2. Recommended for use in peroxide cured coatings, sealants, and PCV-based plastisols. Performance properties include: good adhesion, good chemical resistance, good hardness, good heat resistance and high abrasion resistance.

SR9011 Biological Activity:

1. SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure.

 

2. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism.

3. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver,

 

4. skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia.

 

5. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

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